I was running my iMac display at scaled-up resolution for a few month. (For those who don’t know, you can do that via System Preferences > Displays, switching Resolution over to Scaled, then picking an option to the right of Default.)
While the extra real-estate was great for some application, I’ve now decided that it just wasn’t a good deal for my eyeballs.
(My eyesight has changed sufficiently in the last few years that I cannot wear my regular glasses when I’m sat at the computer, and in fact one eye is focussing slightly further than the other, which creates more issue. Eventually, I will need to get a pair of glasses just for computer work and reading. Long-term, I’m looking at varifocals.)